How to choose composite film for medicine packaging?

Under the general environment of accelerating and improving the unified and authoritative drug safety supervision system, plastic flexible packaging composite film, which is one of the defense lines of drug safety and direct contact with the quality of drugs, will also be paid attention to. Thus, small and application characteristics to the material we pharmaceutically acceptable flexible plastic composite film under the science, for reference use.

  Drug requirements for flexible packaging composite film materials:

1. To prevent the contents from deteriorating, the main measures are to prevent moisture, gas, light, sterile, and seal;

2. In order to ensure the quality of the content and the safety of the filling, packaging, storage and transportation process, the packaging materials are also required to have hygienic properties such as ensuring content stability, heat resistance, and no migration of harmful substances;

3. The material is required to have certain hygienic properties such as tensile resistance, impact resistance, puncture resistance and tear strength.

The types of plastic composite membrane materials used by Chinese and Western medicine :

At present, no single-layer film has the above various functions. A multi-layer composite film or a coating film made by two or more layers of multi-layer composite can take advantage of the shortcomings to meet multiple requirements. The plastic composite film packaging of granules, powders, powders, capsules, etc. of Chinese and Western medicine mainly includes the following varieties.

1.LDPE film

LDPE can be compounded with various polyolefins to make flexible packaging bags, such as a medical liquid packaging bag, the raw material of which is a copolymer of LDPE and ethylene - α olefin.

Advantages: It can withstand high temperature sterilization treatment above 100 ℃ and has good flexibility. Multi-layer composite film made from LDPE , adhesive, PA and other raw materials has similar advantages as PVC and PP , and has a wide range of uses.

2.PP film

PP film can be used as a large number of inner and outer layers of medical flexible packaging composite film.

Advantages: BOPP film has good transparency, heat resistance and barrier properties;

It is used for the outer layer of the composite packaging bag , and it is compounded with LDPE , EVA , EEA , EAA or aluminum foil with good heat sealability , which can greatly improve the rigidity and physical mechanical properties of the composite film. If the BOPP base film is coated with PVDC with excellent moisture resistance and barrier properties , its gas barrier and moisture barrier properties can be greatly improved.

3. CPP film

Cast polypropylene film ( CPP ) has good heat sealability, and is mostly used for the inner layer of composite packaging bags. After vacuum aluminum plating, it can be compounded with BOPP , PET , OPA , and PT . It is an important material for pharmaceutical packaging.

4.PET film

Advantages: A biaxially oriented polyester film of polyester film (PET) has a high mechanical strength and rigidity, high heat resistance, excellent chemical resistance, transparency and very good gloss, water vapor and oxygen permeability The rate is small and has a particularly good taste retention, which is unmatched by all other films.

5.PVDC film

Polyvinylidene chloride film ( PVDC ) is one of the films with the best barrier properties. It is divided into heat-resistant coated films, such as gas barrier PP , CPE , PET and coated PVDC films. PVDC coated composite film has been widely used in pharmaceutical packaging, which can play a role in moisture resistance, taste retention, moisture resistance and so on. The current PVDC on the market is actually a copolymer of vinylidene chloride ( VDC ) and vinyl chloride or acrylic monomers, and the monomer content is usually 75% to 90% .

Advantages: PVDC has the characteristics of transparency, flexibility, oil resistance, chemical resistance, excellent gas barrier and moisture barrier, etc. It is a widely used barrier material for high school.

Application: In high-barrier medical packaging, it is usually used as a coating material. The composite film of 2 ~ 4µmPVDC is coated on PP , CPE , PET film, which can make its breathability and moisture permeability most suitable for the manufacture of pharmaceutical blister Composite packaging bags for packaging films and packaging granules, powders and low-priced drugs.

6. Vacuum aluminum coating

Vacuum aluminized film is a kind of flexible packaging film product that evaporates aluminum onto various base films under high vacuum. The aluminized layer is very thin. Vacuum aluminum coatings such as PETP , CPP , PT , PI , and PE are widely used in the packaging of important powders, granules, and powders . Among them, PETP , CPP , PE vacuum aluminized film is the most used.

Advantages: In addition to the characteristics of a plastic base film, vacuum aluminized soft film packaging also has beautiful decoration and good barrier properties. Especially after various plastic substrates are aluminized, their light transmittance, oxygen permeability and The water vapor transmission rate is reduced by dozens of times or hundreds of times. It is used in medicine packaging to prevent the mold from becoming moldy and wet.

7. CTFE film

Fluorohalogenated hydrocarbon film mainly refers to a copolymer of chlorotrifluorotriene ( CTFE ), which is non-flammable, has excellent barrier properties and is transparent, and has a unique range of applications. There are currently two types of such films, CTFE and ethylene trifluorochloroethylene copolymers. The CTFE film is still soft below -160 ℃, and the melting point is between 180 ~ 204 ℃, which is related to its taste and crystallization degree.

8. Multi-layer structure medical packaging film

Multi-layer structure medical packaging film generally adopts PE / adhesive / PA / adhesive / PE / adhesive / PA / adhesive / PE9 layer structure. PP can also be used instead of PA . Other structures are the same, and the thickness is usually 0.05 ~ 0.4mm . At present, the number of layers of coextruded films is increasing, and many companies have been able to produce 8- layer, 9- layer or even 11- layer medical packaging films.

Examples of several typical medical compound packaging materials are as follows.

â‘ Generally used: BOPP / PE, PET / PE, BOPA / PE, BOPA / CPP, PET / VMCPP, BOPP / VMPET / PE, BOPP / AI / PE .

â‘¡ surgical blade: BOPP / AI / PE, PET / AI / PE.

â‘¢ Blister packaging: PVC / AI, PVC / VC-VA / AI, PP / PVC / PP, PF / PVC / PE.

â‘£Medicine powder, tablets: paper / AI / PE, paper / PE / AI / PE

⑤ Paste: PET / AI / PE .

â‘¥Infusion packaging: PET / PA / CPP, PA / CPP .

 

 

 


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